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ea0022oc3.6 | Pituitary | ECE2010

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Tichomirowa Maria , Barlier Anne , Daly Adrian , Jaffrain-Rea Marie-Lise , Cozzi Renato , Yaneva Maria , Naves Luciana , Ronchi Christina , Sievers Caroline , Maiter Dominique , Montanana Carmen Fajardo , Zacharieva Sabine , Beckers Albert

Methods: We undertook an assessment of patients which were diagnosed with or had their first symptoms of pituitary tumor before the age of 30 and had tumor diameter more than 1 cm without familial history of pituitary adenomas. In patients that consented to genetic analysis, germline mutations in the AIP gene were sought.Results: The study population consisted of 164 patients (61 prolactinomas, 84 somatotropinomas, 16 non-secreting tumors, two pat...

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ea0035oc2.3 | Adrenal clinical | ECE2014

Prognostic value of DNA methylation in adrenocortical carcinomas: an ENSAT study

Assie Guillaume , Jouinot Anne , Libe Rossella , Barreau Olivia , Papathomas Thomas , Hamzaoui Nadim , Sbiera Silviu , Ronchi Christina , Kroiss Matthias , Waldmann Jens , Quinkler Marcus , Beuschlein Felix , Mannelli Massimo , Luconi Michaela , Mantero Franco , Groussin Lionel , Baudin Eric , de Krijger Ronald , Fassnacht Martin , Bertherat Jerome

Background: The prognosis of adrenocortical carcinomas (ACCs) is heterogeneous. Genome-wide methylation analysis of tumor DNA identified a sub-group of ACCs from the French COMETE network with CpG island hypermethylation evoking a CpG island methylator phenotype (CIMP). These ACCs are associated with a poorer prognosis (Barreau, JCEM 2013).The aim was to validate the prognostic value of CIMP in a large multicentric independent cohort from ENSAT (European...

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Endocrine Abstracts

Young patients with sporadic macroadenomas as target population for AIP mutations screening

Prognostic value of DNA methylation in adrenocortical carcinomas: an ENSAT study

BiosciAbstracts